Richard Glynne, Genomics Institute of the Novartis Research Foundation
Finding New Drugs for Kinetoplastid Diseases: Sleeping Sickness, Chagas Disease, and Leishmaniasis
Chagas disease, leishmaniasis and human African trypanosomiasis are caused by related kinetoplastid parasites. We have used unbiased compound screens to find inhibitors of parasite growth. From these screen hits, we have developed lead chemical series, and identified new targets to seed future discovery efforts.